Bioproximity has been a provider of contract scientific research, specializing in biological mass spectrometry and bioinformatics, since 2008. We offer a broad range of proteomic services designed for specific applications. We combine specialized sample handling and sample preparation tools and methods with state-of-the-art instrumentation, cloud-based computational resources and fit-for-purpose data analytic pipelines to yield the best quality data, consistently.

Our clients include over 500 institutions on four continents, including government researchers at institutions including DOD, FDA, NIH, USDA, USGS and VA, academic researchers at institutions including Harvard Medical School and Stanford University, research institutes including J. David Gladstone Institutes and Woods Hole Oceanographic Institution, as well as private companies in the agriculture, biotechnology, energy, food, healthcare and pharmaceutical industries.

We developed Proteome Cluster, an industry-first web application for storing and analyzing tandem mass spectrometry data in the cloud through the use of transient, on-demand, Beowulf compute clusters using the high performance compute instances available via Amazon Web Services to enable highly parallelized data processing. Proteome Cluster can now execute nearly any data processing pipeline for biological mass spectrometry data. Our work has contributed to publications in leading journals including Science, PNAS and Cancer Research.

Over the past 10 years we have consistently expanded our capabilities with the acquisition of new mass spectrometers and the development of new bioinformatic capabilities. We are able to execute custom computing workflows at-scale, in which the user defines the bioinformatic data processing workflow and the data reporting specifications, up to and including figures suitable for scientific publication or compliance reporting.

We are a small, dedicated group of scientists and software engineers, devoted to expanding the real-world applications of biological mass spectrometry. Please contact us to discuss your project aims.

About Proteomics

Proteomics is the study of proteins. Shotgun proteomics is a method for identifying and quantifying proteins and has been optimized by the scientific research community to permit near-global profiling of almost any sample. Using modern methods and instrumentation, many thousands of proteins may be routinely identified at sub-nanogram quantities. Shotgun proteomics is currently used in a wide variety of applications, from discovery of biomarkers for disease diagnosis and prognosis to quality control of bioprocessing pipelines to validation of monoclonal antibodies.